Saturday , April 4 2020

Hematology Practice Quiz

Objective Questions | Hematology Practice Quiz

1 >>All of the following are associated with increased Red Cell ADA (Adenosine Deaminase) level, except: ?

  • (A) DBA
  • (B) SCID
  • (C) AIDS
  • (D) Some cases of hereditary non-spherocytic hemolytic Anemia

2 >>All of the following red cell enzyme deficiencies are inherited as autosomal recessive, except: ?

  • (A) G6PD deficiency
  • (B) PK deficiency
  • (C) TPI deficiency
  • (D) Glucose phosphate isomerase deficiency

3 >>Which of the following is normal form of G6PD? ?

  • (A) G6PD B
  • (B) G6PD Ac.
  • (C) G6PD A+
  • (D) G6PD mediterranea

4 >>Which of the following is true about G6PD? ?

  • (A) Drug induced hemolysis begins after 7 days
  • (B) Heinz bodies are seen in RBCs
  • (C) In the A-form of G6PD hemolytic anemia is self-limited
  • (D) Common (Polymorphic) form have no clinical manifestations

5 >>All of the following is true about red cell enzyme defects, except: ?

  • (A) Basophilic stippling in Red cell is characteristic of pyrimidine’s nucleotidase deficiency
  • (B) Jaundice of glucose phosphate isomerase deficiency respond to phenobarbital
  • (C) Patient’s with glucose phosphate isomerase deficiency respond more to splenectomy
  • (D) Phosphoglycerate kinase is autosomal recessive

6 >>Which one of the following is a feature of chronic extravascular hemolysis? ?

  • (A) Raised serum conjugated bilirubin
  • (B) Low reticulocyte count
  • (C) Hypocellular bone marrow
  • (D) Gall stones

Hematology Practice Quiz

7 >>Which of the following is not a cause of intravascular hemolysis? ?

  • (A) Rh incompatibility
  • (B) ABO incompatibility
  • (C) G6PD deficiency
  • (D) Red cell fragmentation syndrome

8 >>A 10 years old child presented with severe hemolytic anemia after febrile illness. There is marked reticulocytosis and LDH of 10,000 IU/ ml. Characteristically, his total Bilirubin is 0.3 with direct fraction of 0.2 mg/dL. The most like diagnosis is: ?

  • (A) Heme oxygenase deficiency
  • (B) Ferrochelatase deficiency
  • (C) Biliverdin reductase
  • (D) ALA dehydratase

9 >>Which of the following is not a feature of intravascular hemolysis? ?

  • (A) Jaundice
  • (B) Hemosiderin in urine
  • (C) Absent haptoglobin
  • (D) Hemoglobin in urine

10 >>Which of the following is not true about G6PD deficiency? ?

  • (A) Commonly presents as chronic hemolytic anemia
  • (B) Leads to intravascular hemolysis after certain infections
  • (C) Protects against malaria
  • (D) Carrier females have approximately 50% G6PD levels

11 >>Extravascular hemolysis is best characterized by all except: ?

  • (A) Increased LDH
  • (B) Splenomegaly
  • (C) Jaundice
  • (D) Increased plasma hemoglobin

12 >>Which of the following is not true about hemolytic anemia? ?

  • (A) The degree of spherocytosis does not correlates with the severity of hemolysis
  • (B) Alloimmune hemolytic anemia is characterized by positive ICT and DCT may be mildly positive or negative
  • (C) In AIHA most common target is Rh antigen
  • (D) Therapy should not be stopped until the DCT because negative

Hematology Practice Quiz

13 >>All of the following are associated with cold type autoantibody, except: ?

  • (A) Mycoplasma pneumonia
  • (B) Donath-Landsteiner hemolytic anemia
  • (C) Infectious mononucleosis
  • (D) Hodgkin lymphoma

14 >>In CLL the autoimmune hemolytic anemia is due to: ?

  • (A) Warm antibody
  • (B) Cold antibody
  • (C) Mixed cold and warm antibody
  • (D) Occurs only with treatment with purine analogue

15 >>Which of the following is not true about autoimmune hemolytic anemia associated with ?-methyldopa? ?

  • (A) Positive DCT is found in 8-36% of patients
  • (B) Lag period of 3-6 months is present between the start of therapy and development of positive DCT
  • (C) Less that 1% of patients develop hemolytic anemia
  • (D) Hemolytic anemia is due to hapten mechanism

16 >>In CLL patients the risks factors for development of autoimmune hemolytic anemia after purine analogue treatment are all, except: ?

  • (A) Previous exposure prior to Purine analogues
  • (B) Positive DAT prior to therapy
  • (C) Hypogammaglobulinemia
  • (D) High B2 microglobulin

17 >>Which of the following is true about cold agglutinin disease? ?

  • (A) Usually the antibodies are of IgM type
  • (B) Occurs in infectious mononucleosis
  • (C) In-vitro agglutination is maximum at 0-5°C
  • (D) Infectious mononucleosis has cold agglutinin with anti-I, specificity

18 >>Which of the following is not true about AIHA? ?

  • (A) It may be due to drugs
  • (B) Associated with pernicious anemia
  • (C) May complicate B-cell CLL
  • (D) May be associated with IgM antibodies in serum

19 >>What is detected by indirect Coomb’s test? ?

  • (A) Antibodies in serum
  • (B) Antibodies on RBC surface
  • (C) Antigens on RBC surface
  • (D) Antibodies in plasma

Hematology Practice Quiz

20 >>Which of the following is not true about DCT – Negative AIHA? ?

  • (A) Polyspecific AHG (anti human globulin) may not be able to detect this type of AIHA if the type of antibody is IgA or IgM
  • (B) Low affinity IgG autoantibodies
  • (C) Low titre IgG autoantibodies
  • (D) Gel card is not able to detect rare IgA only AIHA

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